Camera-monitor systems (CMS) can be used in motor vehicles to display the driver's rear view on a monitor mounted inside the vehicle. This also offers the possibility of replacing conventional exterior mirrors with suitable CMS and thereby implementing new design concepts with aerodynamic advantages. However, as exterior mirrors are safety-relevant vehicle parts for securing the driver's indirect rear view (requirements specified in UN Regulation No. 46), the question arises whether CMS can provide an equivalent substitute for mirrors. In the scope of this study, CMS and conventional exterior mirrors were compared and assessed in test drives and static tests under different external conditions. On the one hand, the examination of technical aspects, and on the other hand, issues pertaining to the design of the human-machine interaction, were the objects of the study. Two vehicles were available for the trials with passenger vehicles: A vehicle, manufactured in small series, which is already equipped with CMS as sole replacement for the exterior mirrors, as well as a compact class vehicle which had a CMS retrofitted by the car manufacturer in addition to conventionally used exterior mirrors. The latter could be covered exclusively for trips with CMS. A tractor unit with semitrailer was available for the truck trials. The driver's cabin was equipped with a CMS system developed by the vehicle manufacturer. In general, it was shown that it is possible to display the indirect rear view sufficiently for the driver, both for cars and trucks, using CMS which meet specific quality criteria. Depending on the design, it is even possible to receive more information about the rear space from a CMS than is possible with mirror systems. It was also shown that the change from mirrors to CMS requires a certain period of familiarisation. However, this period is relatively short and does not necessarily result in safety-critical situations.