Abteilung Verhalten und Sicherheit im Verkehr
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The 6th RFP project DRUID aimed at supporting European transport policy makers by suggesting scientifically based recommendations to combat impaired driving. The main DRUID objectives were: 1. In-depth analysis of the problem situation with regard to DUI/DUID in Europe; 2. Assessment of prevalence and accident risks of DUI/DUID on the basis of epidemiological and experimental studies; 3. Evaluation of oral fluid screening devices and cost-benefit analysis of a strengthened drug driving enforcement; 4. Development of a classification system for medicines; 5. Evaluation of driver rehabilitation schemes and strategies of licence revocation; 6. Assessment of the effectiveness of new prescribing and dispensing guidelines for medicines; 7. Ddevelopment of policy recommendations on the basis of DRUID results. All in all, the DRUID results revealed that prevalence of psychoactive substance consumption, DUI/DUID, enforcement levels and legal strategies are very heterogeneous in European countries. Nonetheless, DRUID derives general recommendations as base for national solutions.
The DRUID expert consensus established recommendations on how to define limits for psychoactive substance use in traffic. The European DRUID project established a group of experts who are members of national working groups for defining analytical and/or risk thresholds. This group evaluated the results of DRUID, scientific literature and the experience of representatives of several EU Member States and Norway in determining cut-off levels. 1. Cut-offs should be defined for the most frequently used psychoactive substances; 2. In order to achieve compliance of the population towards cut-off regulations, they should be clear and comprehensible, pointing out the risks when used in traffic; 3. Thus, the definition of cut-offs should be based on current scientific knowledge; 4. The lowest substance concentration exerting an effect on driving should be preferred instead of the lowest limit of quantification/ detection; 5. For all psychoactive substances including alcohol, the same risk should be accepted. When a country intends to determine per se cut-off levels, several considerations have to be taken into account. From a scientific point of view, the same risk should be anticipated for all psychoactive substances including alcohol. Nevertheless, every cut-off discussion should address the question if the DRUID approach, to determine risk thresholds equivalent to alcohol limits, is feasible for the respective case.
Der Nachweis von Geringstmengen Benzoylecgonin (BZE) deutet bei Gelegenheitskonsumenten nicht zwingend auf eine akute Verkehrssicherheitsgefährdung hin, zumal der kokainerge Metabolismus starken interindividuellen und geschlechtsspezifischen Schwankungen unterliegt (BOWMAN et al., 1999; LUKAS et al., 1996; HAMILTON et al., 1977) und die gemessene BZE-Konzentration vom Zeitpunkt der Kokaineinnahme und der Höhe der eingenommenen Kokaindosis abhängt (ITEN, 1994; AMBRE, 1985). Eine starke interindividuelle Varianz wurde auch bei der Einlagerung von Kokain oder BZE in Haaren festgestellt (HARKEY, 1995). Im Gegensatz zu den Gelegenheitskonsumenten weisen Kokainabhängige in einem Abstinenzraum von mindestens drei Monaten neurologische, neuropsychologische und teilweise auch psychiatrische Defizite auf, die verkehrssicherheitsrelevant sind. Somit würde bei bekannter Kokainabhängigkeit der Nachweis von Geringstmengen BZE bereits ein ausreichender Indikator für eine verkehrssicherheitsrelevante Funktionsbeeinträchtigung sein.